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Insights into APC/C: from cellular function to diseases and therapeutics

Overview of attention for article published in Cell Division, July 2016
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Mentioned by

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2 tweeters

Citations

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51 Dimensions

Readers on

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117 Mendeley
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Title
Insights into APC/C: from cellular function to diseases and therapeutics
Published in
Cell Division, July 2016
DOI 10.1186/s13008-016-0021-6
Pubmed ID
Authors

Zhuan Zhou, Mingjing He, Anil A. Shah, Yong Wan

Abstract

Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein ligase that targets different substrates for ubiquitylation and therefore regulates a variety of cellular processes such as cell division, differentiation, genome stability, energy metabolism, cell death, autophagy as well as carcinogenesis. Activity of APC/C is principally governed by two WD-40 domain proteins, Cdc20 and Cdh1, in and beyond cell cycle. In the past decade, the results based on numerous biochemical, 3D structural, mouse genetic and small molecule inhibitor studies have largely attracted our attention into the emerging role of APC/C and its regulation in biological function, human diseases and potential therapeutics. This review will aim to summarize some recently reported insights into APC/C in regulating cellular function, connection of its dysfunction with human diseases and its implication of therapeutics.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
India 1 <1%
Unknown 115 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 21%
Student > Bachelor 18 15%
Student > Master 17 15%
Researcher 15 13%
Student > Doctoral Student 8 7%
Other 14 12%
Unknown 21 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 40 34%
Agricultural and Biological Sciences 28 24%
Neuroscience 7 6%
Medicine and Dentistry 6 5%
Unspecified 3 3%
Other 10 9%
Unknown 23 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 July 2016.
All research outputs
#4,038,192
of 8,078,414 outputs
Outputs from Cell Division
#26
of 57 outputs
Outputs of similar age
#130,232
of 259,426 outputs
Outputs of similar age from Cell Division
#1
of 1 outputs
Altmetric has tracked 8,078,414 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 57 research outputs from this source. They receive a mean Attention Score of 2.4. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 259,426 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them