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Atorvastatin treatment is effective when used in combination with mefloquine in an experimental cerebral malaria murine model

Overview of attention for article published in Malaria Journal, January 2012
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Title
Atorvastatin treatment is effective when used in combination with mefloquine in an experimental cerebral malaria murine model
Published in
Malaria Journal, January 2012
DOI 10.1186/1475-2875-11-13
Pubmed ID
Authors

Jean-Baptiste Souraud, Sébastien Briolant, Jérome Dormoi, Joel Mosnier, Hélène Savini, Eric Baret, Rémy Amalvict, Raoulin Soulard, Christophe Rogier, Bruno Pradines

Abstract

One of the major complications of Plasmodium falciparum infection is cerebral malaria (CM), which causes one million deaths worldwide each year, results in long-term neurological sequelae and the treatment for which is only partially effective. Statins are recognized to have an immunomodulatory action, attenuate sepsis and have a neuroprotective effect. Atorvastatin (AVA) has shown in vitro anti-malarial activity and has improved the activity of mefloquine (MQ) and quinine.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 2%
United Kingdom 1 2%
Unknown 46 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 25%
Student > Master 11 23%
Student > Ph. D. Student 8 17%
Professor > Associate Professor 3 6%
Student > Doctoral Student 2 4%
Other 8 17%
Unknown 4 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 31%
Medicine and Dentistry 13 27%
Immunology and Microbiology 5 10%
Biochemistry, Genetics and Molecular Biology 2 4%
Environmental Science 1 2%
Other 4 8%
Unknown 8 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 October 2012.
All research outputs
#15,251,976
of 22,679,690 outputs
Outputs from Malaria Journal
#4,454
of 5,540 outputs
Outputs of similar age
#161,887
of 243,284 outputs
Outputs of similar age from Malaria Journal
#58
of 70 outputs
Altmetric has tracked 22,679,690 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,540 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,284 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.