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The potential for selective pharmacological therapies through biased receptor signaling

Overview of attention for article published in BMC Pharmacology and Toxicology, August 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#37 of 251)
  • High Attention Score compared to outputs of the same age (85th percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

Mentioned by

blogs
1 blog
twitter
1 tweeter

Citations

dimensions_citation
38 Dimensions

Readers on

mendeley
62 Mendeley
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Title
The potential for selective pharmacological therapies through biased receptor signaling
Published in
BMC Pharmacology and Toxicology, August 2012
DOI 10.1186/2050-6511-13-3
Pubmed ID
Authors

Terry Kenakin

Abstract

The discovery that not all agonists uniformly activate cellular signaling pathways (biased signaling) has greatly changed the drug discovery process for agonists and the strategy for treatment of disease with agonists. Technological advances have enabled complex receptor behaviors to be viewed independently and through these assays, the bias for an agonist can be quantified. It is predicted that therapeutic phenotypes will be linked, through translational studies, to quantified scales of bias to guide medicinal chemists in the drug discovery process.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 3%
Canada 2 3%
Bulgaria 1 2%
Netherlands 1 2%
Unknown 56 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 18 29%
Student > Ph. D. Student 13 21%
Student > Bachelor 7 11%
Other 5 8%
Student > Doctoral Student 3 5%
Other 10 16%
Unknown 6 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 29%
Medicine and Dentistry 9 15%
Biochemistry, Genetics and Molecular Biology 7 11%
Chemistry 5 8%
Pharmacology, Toxicology and Pharmaceutical Science 5 8%
Other 11 18%
Unknown 7 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2012.
All research outputs
#1,833,159
of 12,434,464 outputs
Outputs from BMC Pharmacology and Toxicology
#37
of 251 outputs
Outputs of similar age
#18,506
of 128,383 outputs
Outputs of similar age from BMC Pharmacology and Toxicology
#3
of 11 outputs
Altmetric has tracked 12,434,464 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 251 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 128,383 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.