Title |
A meta-analysis of genome-wide association studies of follicular lymphoma
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Published in |
BMC Genomics, October 2012
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DOI | 10.1186/1471-2164-13-516 |
Pubmed ID | |
Authors |
Christine F Skibola, Lucia Conde, Jia-Nee Foo, Jacques Riby, Keith Humphreys, Fenna CM Sillé, Hatef Darabi, Sylvia Sanchez, Henrik Hjalgrim, Jianjun Liu, Paige M Bracci, Karin E Smedby |
Abstract |
B-cell non-Hodgkin lymphoma represents a diverse group of hematological malignancies, of which follicular lymphoma (FL) is one of the most common subtypes. Family and epidemiological studies suggest an important genetic role in the etiology of FL. In recent genome-wide association studies (GWAS) of FL, several genetic susceptibility loci have been identified on chromosome 6p21.33 (rs6457327) and 6p21.32 (rs10484561, rs2647012) in the human leukocyte antigen class I and class II regions. To identify new genetic variants and further elucidate the genetic basis of FL, a meta-analysis was performed of the top 1000 SNPs associated with FL risk from two GWAS in the US, Denmark and Sweden (592 cases, 1541 controls), with independent validation in 107 cases and 681 controls. |
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United States | 1 | 100% |
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Scientists | 1 | 100% |
Mendeley readers
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Researcher | 11 | 37% |
Other | 4 | 13% |
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Professor > Associate Professor | 3 | 10% |
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Unspecified | 1 | 3% |
Other | 2 | 7% |
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