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Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H ß-synuclein

Overview of attention for article published in Molecular Brain, September 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • Good Attention Score compared to outputs of the same age and source (70th percentile)

Mentioned by

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1 X user
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3 patents

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39 Mendeley
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Title
Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H ß-synuclein
Published in
Molecular Brain, September 2012
DOI 10.1186/1756-6606-5-34
Pubmed ID
Authors

Akio Sekigawa, Masayo Fujita, Kazunari Sekiyama, Yoshiki Takamatsu, Taku Hatano, Edward Rockenstein, Albert R La Spada, Eliezer Masliah, Makoto Hashimoto

Abstract

Axonopathy is critical in the early pathogenesis of neurodegenerative diseases, including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Axonal swellings such as globules and spheroids are a distinct feature of axonopathy and our recent study showed that transgenic (tg) mice expressing DLB-linked P123H β-synuclein (P123H βS) were characterized by P123H βS-immunoreactive axonal swellings (P123H βS-globules). Therefore, the objectives of this study were to evaluate α-synuclein (αS)-immunoreactive axonal swellings (αS-globules) in the brains of tg mice expressing human wild-type αS and to compare them with the globules in P123H βS tg mice.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 39 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 36%
Student > Ph. D. Student 6 15%
Student > Bachelor 3 8%
Professor > Associate Professor 2 5%
Professor 1 3%
Other 2 5%
Unknown 11 28%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 26%
Medicine and Dentistry 6 15%
Neuroscience 5 13%
Biochemistry, Genetics and Molecular Biology 3 8%
Chemistry 2 5%
Other 1 3%
Unknown 12 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 February 2021.
All research outputs
#3,099,561
of 22,679,690 outputs
Outputs from Molecular Brain
#183
of 1,103 outputs
Outputs of similar age
#22,463
of 171,752 outputs
Outputs of similar age from Molecular Brain
#3
of 10 outputs
Altmetric has tracked 22,679,690 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,103 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 171,752 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.