Title |
The safety of Homnawakod herbal formula containing Aristolochia tagala Cham. in Wistar rats
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Published in |
BMC Complementary Medicine and Therapies, October 2012
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DOI | 10.1186/1472-6882-12-170 |
Pubmed ID | |
Authors |
Pinpat Tripatara, Winita Onlamul, Suksalin Booranasubkajorn, Jantanee Wattanarangsan, Sukit Huabprasert, Natchagorn Lumlerdkij, Pravit Akarasereenont, Tawee Laohapand |
Abstract |
A dried root of Aristolochia tagala Cham. (ATC) is often used in Thai traditional medicine as an antipyretic, anti-inflammatory agent, muscle relaxant, appetite-enhancing agent, and analeptic. Homnawakod, an important herbal recipe, originally contains ATC in its formula, however, some Aristolochia species have been reported to cause nephrotoxicity due to aristolochic acid (AA) and its derivatives, resulting in ATC removal from all formulae. Therefore, this study investigates the chemical profiles of ATC, the original (HNK+ATC) and the present Homnawakod Ayurved Siriraj Herbal Formulary™ (HNK), and investigates whether they could cause nephrotoxicity or aggravate LPS-induced organ injuries in vivo. |
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