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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Enhanced top-down characterization of histone post-translational modifications
|
|---|---|
| Published in |
Genome Biology, October 2012
|
| DOI | 10.1186/gb-2012-13-10-r86 |
| Pubmed ID | |
| Authors |
Zhixin Tian, Nikola Tolić, Rui Zhao, Ronald J Moore, Shawna M Hengel, Errol W Robinson, David L Stenoien, Si Wu, Richard D Smith, Ljiljana Paša-Tolić |
| Abstract |
ABSTRACT: Post-translational modifications (PTMs) of core histones work synergistically to fine tune chromatin structure and function, generating a so-called histone code that can be interpreted by a variety of chromatin interacting proteins. We report a novel online two-dimensional liquid chromatography-tandem mass spectrometry (2D LC-MS/MS) platform for high-throughput and sensitive characterization of histone PTMs at the intact protein level. The platform enables unambiguous identification of 708 histone isoforms from a single 2D LC-MS/MS analysis of 7.5 µg purified core histones. The throughput and sensitivity of comprehensive histone modification characterization is dramatically improved compared with more traditional platforms. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 67% |
| United States | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 147 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 5% |
| United Kingdom | 3 | 2% |
| France | 2 | 1% |
| Belgium | 2 | 1% |
| Portugal | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 131 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 46 | 31% |
| Researcher | 37 | 25% |
| Student > Master | 17 | 12% |
| Professor | 9 | 6% |
| Professor > Associate Professor | 9 | 6% |
| Other | 19 | 13% |
| Unknown | 10 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 59 | 40% |
| Chemistry | 30 | 20% |
| Biochemistry, Genetics and Molecular Biology | 24 | 16% |
| Computer Science | 6 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
| Other | 11 | 7% |
| Unknown | 13 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 October 2012.
All research outputs
#15,983,785
of 25,374,917 outputs
Outputs from Genome Biology
#3,995
of 4,467 outputs
Outputs of similar age
#116,406
of 191,479 outputs
Outputs of similar age from Genome Biology
#50
of 55 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 36th percentile – i.e., 36% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 191,479 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.