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Prolonged FGF signaling is necessary for lung and liver induction in Xenopus

Overview of attention for article published in BMC Developmental Biology, September 2012
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Title
Prolonged FGF signaling is necessary for lung and liver induction in Xenopus
Published in
BMC Developmental Biology, September 2012
DOI 10.1186/1471-213x-12-27
Pubmed ID
Authors

Emily T Shifley, Alan P Kenny, Scott A Rankin, Aaron M Zorn

Abstract

FGF signaling plays numerous roles during organogenesis of the embryonic gut tube. Mouse explant studies suggest that different thresholds of FGF signaling from the cardiogenic mesoderm induce lung, liver, and pancreas lineages from the ventral foregut progenitor cells. The mechanisms that regulate FGF dose in vivo are unknown. Here we use Xenopus embryos to examine the hypothesis that a prolonged duration of FGF signaling from the mesoderm is required to induce foregut organs.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 8%
Brazil 1 3%
Unknown 35 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 26%
Student > Ph. D. Student 8 21%
Student > Bachelor 4 10%
Professor 4 10%
Student > Master 3 8%
Other 6 15%
Unknown 4 10%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 16 41%
Agricultural and Biological Sciences 13 33%
Physics and Astronomy 2 5%
Medicine and Dentistry 2 5%
Computer Science 1 3%
Other 1 3%
Unknown 4 10%