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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Neutropenic sepsis is associated with distinct clinical and biological characteristics: a cohort study of severe sepsis
|
|---|---|
| Published in |
Critical Care, July 2016
|
| DOI | 10.1186/s13054-016-1398-y |
| Pubmed ID | |
| Authors |
John P. Reilly, Brian J. Anderson, Kristin M. Hudock, Thomas G. Dunn, Altaf Kazi, Anna Tommasini, Dudley Charles, Michael G. S. Shashaty, Mark E. Mikkelsen, Jason D. Christie, Nuala J. Meyer |
| Abstract |
Immunocompromised patients who develop sepsis while neutropenic are at high risk for morbidity and mortality; however, it is unknown if neutropenic sepsis is associated with distinct clinical and biological characteristics. We conducted a prospective cohort study of patients admitted to the medical intensive care unit of an academic medical center with severe sepsis. Patients were followed for the development of acute respiratory distress syndrome (ARDS), acute kidney injury (AKI), and mortality. Plasma proteins, representing the host inflammatory response, anti-inflammatory response, and endothelial leak were measured in 30 % of subjects. Clinical characteristics and plasma protein concentrations of patients with neutropenia at enrollment were compared to patients without neutropenia. Of 797 subjects enrolled, 103 (13 %) were neutropenic at ICU admission. The neutropenic subjects were more often in shock, admitted from the hospital ward, had higher APACHE III scores, and more likely bacteremic. Neutropenia was an independent risk factor for AKI (RR 1.28; 95 % CI 1.04, 1.57; p = 0.03), but not ARDS (RR 0.90; 95 % CI 0.70, 1.17; p = 0.42) or 30-day mortality (RR 1.05; 95 % CI 0.85, 1.31; p = 0.65). Neutropenic subjects had higher plasma interleukin (IL)-6 (457 vs. 249 pg/ml; p = 0.03), IL-8 (581 vs. 94 pg/ml; p <0.001), and granulocyte colony-stimulating factor (G-CSF) (3624 vs. 99 pg/ml; p <0.001). Angiopoietin-2 and IL-1 receptor antagonist concentrations did not differ between groups. Neutropenic sepsis is associated with a higher AKI risk and concentrations of inflammatory mediators IL-6, IL-8, and G-CSF relative to non-neutropenic patients. These differences may have implications for future therapies targeting neutropenic sepsis. |
X Demographics
The data shown below were collected from the profiles of 64 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 9 | 14% |
| Mexico | 5 | 8% |
| United States | 5 | 8% |
| Spain | 3 | 5% |
| Australia | 2 | 3% |
| Italy | 2 | 3% |
| Malaysia | 2 | 3% |
| Peru | 1 | 2% |
| Vietnam | 1 | 2% |
| Other | 8 | 13% |
| Unknown | 26 | 41% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 41 | 64% |
| Practitioners (doctors, other healthcare professionals) | 18 | 28% |
| Scientists | 3 | 5% |
| Science communicators (journalists, bloggers, editors) | 2 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Russia | 1 | <1% |
| South Africa | 1 | <1% |
| Unknown | 99 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 13% |
| Student > Master | 12 | 12% |
| Student > Bachelor | 11 | 11% |
| Other | 9 | 9% |
| Student > Ph. D. Student | 8 | 8% |
| Other | 21 | 21% |
| Unknown | 28 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 48 | 47% |
| Nursing and Health Professions | 8 | 8% |
| Immunology and Microbiology | 4 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Engineering | 2 | 2% |
| Other | 7 | 7% |
| Unknown | 30 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 45. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2023.
All research outputs
#930,908
of 25,371,288 outputs
Outputs from Critical Care
#713
of 6,554 outputs
Outputs of similar age
#18,122
of 377,559 outputs
Outputs of similar age from Critical Care
#33
of 116 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 377,559 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 116 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.