Title |
Effect of analgesic therapy on clinical outcome measures in a randomized controlled trial using client-owned dogs with hip osteoarthritis
|
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Published in |
BMC Veterinary Research, October 2012
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DOI | 10.1186/1746-6148-8-185 |
Pubmed ID | |
Authors |
Sarah Malek, Susannah J Sample, Zeev Schwartz, Brett Nemke, Peer B Jacobson, Elizabeth M Cozzi, Susan L Schaefer, Jason A Bleedorn, Gerianne Holzman, Peter Muir |
Abstract |
Pain and impaired mobility because of osteoarthritis (OA) is common in dogs and humans. Efficacy studies of analgesic drug treatment of dogs with naturally occurring OA may be challenging, as a caregiver placebo effect is typically evident. However, little is known about effect sizes of common outcome-measures in canine clinical trials evaluating treatment of OA pain. Forty-nine client-owned dogs with hip OA were enrolled in a randomized, double-blinded placebo-controlled prospective trial. After a 1 week baseline period, dogs were randomly assigned to a treatment (ABT-116 - transient receptor potential vanilloid 1 (TRPV1) antagonist, Carprofen - non-steroidal anti-inflammatory drug (NSAID), Tramadol - synthetic opiate, or Placebo) for 2 weeks. Outcome-measures included physical examination parameters, owner questionnaire, activity monitoring, gait analysis, and use of rescue medication. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Unknown | 174 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 25 | 14% |
Researcher | 24 | 14% |
Student > Bachelor | 24 | 14% |
Other | 13 | 7% |
Student > Ph. D. Student | 13 | 7% |
Other | 32 | 18% |
Unknown | 44 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 52 | 30% |
Medicine and Dentistry | 31 | 18% |
Agricultural and Biological Sciences | 13 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
Psychology | 3 | 2% |
Other | 18 | 10% |
Unknown | 54 | 31% |