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Distinct Roles of Synapsin I and Synapsin II during Neuronal Development

Overview of attention for article published in Molecular Medicine, January 1998
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  • High Attention Score compared to outputs of the same age (84th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

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1 blog

Citations

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114 Dimensions

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66 Mendeley
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Title
Distinct Roles of Synapsin I and Synapsin II during Neuronal Development
Published in
Molecular Medicine, January 1998
DOI 10.1007/bf03401726
Pubmed ID
Authors

Adriana Ferreira, Lih-Shen Chin, Lian Li, Lorene M. Lanier, Kenneth S. Kosik, Paul Greengard

Abstract

The synapsins are a family of neuron-specific proteins, associated with the cytoplasmic surface of synaptic vesicles, which have been shown to regulate neurotransmitter release in mature synapses and to accelerate development of the nervous system. Using neuronal cultures from mice lacking synapsin I, synapsin II, or both synapsins I and II, we have now found that synapsin I and synapsin II play distinct roles in neuronal development. Deletion of synapsin II, but not synapsin I, greatly retarded axon formation. Conversely, deletion of synapsin I, but not synapsin II, greatly retarded synapse formation. Remarkably, the deletion of both synapsins led to partial restoration of the wild phenotype. The results suggest that the synapsins play separate but coordinated developmental roles.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 3%
United States 1 2%
Unknown 63 95%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 13 20%
Student > Ph. D. Student 10 15%
Professor 8 12%
Student > Master 7 11%
Researcher 6 9%
Other 9 14%
Unknown 13 20%
Readers by discipline Count As %
Neuroscience 15 23%
Agricultural and Biological Sciences 14 21%
Biochemistry, Genetics and Molecular Biology 9 14%
Medicine and Dentistry 5 8%
Engineering 2 3%
Other 5 8%
Unknown 16 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2021.
All research outputs
#6,599,199
of 25,382,440 outputs
Outputs from Molecular Medicine
#320
of 1,206 outputs
Outputs of similar age
#14,351
of 94,811 outputs
Outputs of similar age from Molecular Medicine
#3
of 12 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 1,206 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,811 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.