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Modulation of medial prefrontal cortical activity using in vivo recordings and optogenetics

Overview of attention for article published in Molecular Brain, October 2012
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Title
Modulation of medial prefrontal cortical activity using in vivo recordings and optogenetics
Published in
Molecular Brain, October 2012
DOI 10.1186/1756-6606-5-36
Pubmed ID
Authors

Guangchen Ji, Volker Neugebauer

Abstract

The medial prefrontal cortex (mPFC) serves major executive functions. mPFC output to subcortical brain areas such as the amygdala controls emotional processing and plays an important role in fear extinction. Impaired mPFC function correlates with extinction deficits in anxiety disorders such as PTSD and with cognitive decision-making deficits in neuropsychiatric disorders and persistent pain. Controlling mPFC output is a desirable therapeutic goal in neuropsychiatric disorders but functional differences of cell types (pyramidal cells and interneurons) and regions (infralimbic and prelimbic) represent a challenge. This electrophysiological study used optogenetics for the cell- and region-specific modulation of mPFC pyramidal output in the intact anesthetized animal.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 305 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 6 2%
France 1 <1%
Kazakhstan 1 <1%
Netherlands 1 <1%
United Kingdom 1 <1%
Brazil 1 <1%
China 1 <1%
Poland 1 <1%
Unknown 292 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 88 29%
Researcher 55 18%
Student > Master 45 15%
Student > Bachelor 30 10%
Student > Doctoral Student 20 7%
Other 39 13%
Unknown 28 9%
Readers by discipline Count As %
Neuroscience 99 32%
Agricultural and Biological Sciences 98 32%
Psychology 33 11%
Medicine and Dentistry 18 6%
Nursing and Health Professions 4 1%
Other 16 5%
Unknown 37 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2013.
All research outputs
#15,739,529
of 25,373,627 outputs
Outputs from Molecular Brain
#552
of 1,198 outputs
Outputs of similar age
#115,019
of 192,239 outputs
Outputs of similar age from Molecular Brain
#6
of 12 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,198 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 192,239 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.