Title |
The extracellular Leucine-Rich Repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns
|
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Published in |
BMC Genomics, September 2007
|
DOI | 10.1186/1471-2164-8-320 |
Pubmed ID | |
Authors |
Jackie Dolan, Karen Walshe, Samantha Alsbury, Karsten Hokamp, Sean O'Keeffe, Tatsuya Okafuji, Suzanne FC Miller, Guy Tear, Kevin J Mitchell |
Abstract |
Leucine-rich repeats (LRRs) are highly versatile and evolvable protein-ligand interaction motifs found in a large number of proteins with diverse functions, including innate immunity and nervous system development. Here we catalogue all of the extracellular LRR (eLRR) proteins in worms, flies, mice and humans. We use convergent evidence from several transmembrane-prediction and motif-detection programs, including a customised algorithm, LRRscan, to identify eLRR proteins, and a hierarchical clustering method based on TribeMCL to establish their evolutionary relationships. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Ireland | 1 | 20% |
Unknown | 4 | 80% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 80% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 2% |
India | 2 | 1% |
United States | 2 | 1% |
Denmark | 1 | <1% |
Egypt | 1 | <1% |
Japan | 1 | <1% |
Spain | 1 | <1% |
Unknown | 174 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 54 | 29% |
Researcher | 28 | 15% |
Student > Bachelor | 19 | 10% |
Student > Master | 16 | 9% |
Professor | 11 | 6% |
Other | 36 | 19% |
Unknown | 21 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 74 | 40% |
Biochemistry, Genetics and Molecular Biology | 38 | 21% |
Neuroscience | 16 | 9% |
Medicine and Dentistry | 14 | 8% |
Immunology and Microbiology | 5 | 3% |
Other | 15 | 8% |
Unknown | 23 | 12% |