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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Local and systemic immunological parameters associated with remission of asthma symptoms in children
|
|---|---|
| Published in |
Allergy, Asthma & Clinical Immunology, October 2012
|
| DOI | 10.1186/1710-1492-8-16 |
| Pubmed ID | |
| Authors |
Susan Waserman, Parameswaran Nair, Denis Snider, Mary Conway, Lata Jayaram, Lynn M McCleary, Jerry Dolovich, Frederick E Hargreave, Jean S Marshall |
| Abstract |
The immunological and clinical parameters that are associated with asthma remission are poorly understood. The cytokine and local mediator changes associated with the resolution of asthma symptoms were examined in three groups of subjects 12-18 years of age (n = 15 in each group): (a) continuing asthma group (CA) who had persistent symptoms since early childhood, (b) an age, sex and atopic status-matched group who had persistent symptoms in early childhood but in whom these had resolved (RA), and (c) a non-atopic, non-asthmatic control group. Clinical parameters, sputum cell counts, peripheral blood mononuclear cell (PBMC) cytokine production and activation marker expression were determined. All of the CA had methacholine airway hyperresponsiveness compared with only half of the RA subjects. The CA showed elevated numbers of eosinophils and increased ECP and IL-5 in sputum, which were not observed in the RA. PBMC cytokine studies revealed increased production of the type 1 cytokines IL-12, IFN-γ and TNF-α in the CA group compared with the RA group, under a range of activation conditions, however, the production of IL-4 and IL-5 were unchanged. These findings suggest that decreased type 1 cytokine expression as well as decreased eosinophilic inflammation is associated with the resolution of asthma symptoms. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 6% |
| Unknown | 16 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 29% |
| Student > Master | 4 | 24% |
| Professor > Associate Professor | 2 | 12% |
| Student > Ph. D. Student | 2 | 12% |
| Student > Doctoral Student | 1 | 6% |
| Other | 3 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 7 | 41% |
| Immunology and Microbiology | 2 | 12% |
| Environmental Science | 1 | 6% |
| Agricultural and Biological Sciences | 1 | 6% |
| Mathematics | 1 | 6% |
| Other | 2 | 12% |
| Unknown | 3 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 October 2012.
All research outputs
#22,778,604
of 25,394,764 outputs
Outputs from Allergy, Asthma & Clinical Immunology
#885
of 925 outputs
Outputs of similar age
#172,297
of 192,302 outputs
Outputs of similar age from Allergy, Asthma & Clinical Immunology
#14
of 14 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 925 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 192,302 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.