Title |
A proof-of-concept clinical study examining the NRF2 activator sulforaphane against neutrophilic airway inflammation
|
---|---|
Published in |
Respiratory Research, July 2016
|
DOI | 10.1186/s12931-016-0406-8 |
Pubmed ID | |
Authors |
Charity G. Duran, Allison J. Burbank, Katherine H. Mills, Heather R. Duckworth, Maria M. Aleman, Matthew J. Kesic, David B. Peden, Yinghao Pan, Haibo Zhou, Michelle L. Hernandez |
Abstract |
Sulforaphane (SFN), a naturally occurring isothiocyanate found in cruciferous vegetables, is implicated as a possible therapy for airway inflammation via induction of the transcription factor NF-E2-related factor 2 (NRF2). In this proof-of-concept clinical study, we show that supplementation of SFN with broccoli sprout homogenate in healthy human subjects did not induce expression of antioxidant genes or protect against neutrophilic airway inflammation in an ozone-exposure model. Therefore, dietary sulforaphane supplementation is not a promising candidate for larger scale clinical trials targeting airway inflammation. NCT01625130 . Registered 19 June, 2012. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 3 | 75% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
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United States | 1 | 1% |
Unknown | 70 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 12 | 17% |
Researcher | 7 | 10% |
Student > Master | 7 | 10% |
Student > Doctoral Student | 5 | 7% |
Student > Ph. D. Student | 4 | 6% |
Other | 14 | 20% |
Unknown | 22 | 31% |
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Pharmacology, Toxicology and Pharmaceutical Science | 6 | 8% |
Environmental Science | 3 | 4% |
Agricultural and Biological Sciences | 3 | 4% |
Other | 11 | 15% |
Unknown | 25 | 35% |