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A Toll/IL-1R/resistance domain-containing thioredoxin regulates phagocytosis in Entamoeba histolytica

Overview of attention for article published in Parasites & Vectors, October 2012
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Title
A Toll/IL-1R/resistance domain-containing thioredoxin regulates phagocytosis in Entamoeba histolytica
Published in
Parasites & Vectors, October 2012
DOI 10.1186/1756-3305-5-224
Pubmed ID
Authors

Ismael Mancilla-Herrera, Alfonso Méndez-Tenorio, Isabel Wong-Baeza, Alexis P Jiménez-Uribe, Marcela Alcántara-Hernández, Ramon Ocadiz-Ruiz, Mario A Moreno-Eutimio, Lourdes A Arriaga-Pizano, Constantino López-Macías, Jorge González-y-Merchand, Armando Isibasi

Abstract

Entamoeba histolytica is a protozoan parasite that infects humans and causes amebiasis affecting developing countries. Phagocytosis of epithelial cells, erythrocytes, leucocytes, and commensal microbiota bacteria is a major pathogenic mechanism used by this parasite. A Toll/IL-1R/Resistance (TIR) domain-containing protein is required in phagocytosis in the social ameba Dictyostelium discoideum, an ameba closely related to Entamoeba histolytica in phylogeny. In insects and vertebrates, TIR domain-containing proteins regulate phagocytic and cell activation. Therefore, we investigated whether E. histolytica expresses TIR domain-containing molecules that may be involved in the phagocytosis of erythrocytes and bacteria.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Iran, Islamic Republic of 1 3%
Portugal 1 3%
Unknown 28 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 20%
Other 4 13%
Student > Master 4 13%
Student > Doctoral Student 3 10%
Student > Ph. D. Student 3 10%
Other 6 20%
Unknown 4 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 33%
Biochemistry, Genetics and Molecular Biology 4 13%
Immunology and Microbiology 2 7%
Arts and Humanities 1 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 7 23%
Unknown 5 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2012.
All research outputs
#17,667,907
of 22,681,577 outputs
Outputs from Parasites & Vectors
#3,780
of 5,430 outputs
Outputs of similar age
#125,825
of 172,974 outputs
Outputs of similar age from Parasites & Vectors
#30
of 46 outputs
Altmetric has tracked 22,681,577 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,430 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,974 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.