Title |
A Toll/IL-1R/resistance domain-containing thioredoxin regulates phagocytosis in Entamoeba histolytica
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Published in |
Parasites & Vectors, October 2012
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DOI | 10.1186/1756-3305-5-224 |
Pubmed ID | |
Authors |
Ismael Mancilla-Herrera, Alfonso Méndez-Tenorio, Isabel Wong-Baeza, Alexis P Jiménez-Uribe, Marcela Alcántara-Hernández, Ramon Ocadiz-Ruiz, Mario A Moreno-Eutimio, Lourdes A Arriaga-Pizano, Constantino López-Macías, Jorge González-y-Merchand, Armando Isibasi |
Abstract |
Entamoeba histolytica is a protozoan parasite that infects humans and causes amebiasis affecting developing countries. Phagocytosis of epithelial cells, erythrocytes, leucocytes, and commensal microbiota bacteria is a major pathogenic mechanism used by this parasite. A Toll/IL-1R/Resistance (TIR) domain-containing protein is required in phagocytosis in the social ameba Dictyostelium discoideum, an ameba closely related to Entamoeba histolytica in phylogeny. In insects and vertebrates, TIR domain-containing proteins regulate phagocytic and cell activation. Therefore, we investigated whether E. histolytica expresses TIR domain-containing molecules that may be involved in the phagocytosis of erythrocytes and bacteria. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Iran, Islamic Republic of | 1 | 3% |
Portugal | 1 | 3% |
Unknown | 28 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 20% |
Other | 4 | 13% |
Student > Master | 4 | 13% |
Student > Doctoral Student | 3 | 10% |
Student > Ph. D. Student | 3 | 10% |
Other | 6 | 20% |
Unknown | 4 | 13% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 10 | 33% |
Biochemistry, Genetics and Molecular Biology | 4 | 13% |
Immunology and Microbiology | 2 | 7% |
Arts and Humanities | 1 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Other | 7 | 23% |
Unknown | 5 | 17% |