Title |
Activation of AKT by hypoxia: a potential target for hypoxic tumors of the head and neck
|
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Published in |
BMC Cancer, October 2012
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DOI | 10.1186/1471-2407-12-463 |
Pubmed ID | |
Authors |
Hanneke Stegeman, Johannes H Kaanders, Deric L Wheeler, Albert J van der Kogel, Marieke M Verheijen, Stijn J Waaijer, Mari Iida, Reidar Grénman, Paul N Span, Johan Bussink |
Abstract |
Only a minority of cancer patients benefits from the combination of EGFR-inhibition and radiotherapy in head and neck squamous cell carcinoma (HNSCC). A potential resistance mechanism is activation of EGFR and/or downstream pathways by stimuli in the microenvironment. The aim of this study was to find molecular targets induced by the microenvironment by determining the in vitro and in vivo expression of proteins of the EGFR-signaling network in 6 HNSCC lines. As hypoxia is an important microenvironmental parameter associated with poor outcome in solid tumors after radiotherapy, we investigated the relationship with hypoxia in vitro and in vivo. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 2% |
France | 1 | 2% |
Unknown | 48 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 24% |
Student > Bachelor | 8 | 16% |
Student > Ph. D. Student | 8 | 16% |
Student > Master | 6 | 12% |
Other | 4 | 8% |
Other | 8 | 16% |
Unknown | 4 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 28% |
Medicine and Dentistry | 14 | 28% |
Biochemistry, Genetics and Molecular Biology | 8 | 16% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 8% |
Chemistry | 3 | 6% |
Other | 3 | 6% |
Unknown | 4 | 8% |