Title |
Could dysbiosis of inflammatory and anti-inflammatory gut bacteria have an implications in the development of type 2 diabetes? A pilot investigation
|
---|---|
Published in |
BMC Research Notes, February 2021
|
DOI | 10.1186/s13104-021-05466-2 |
Pubmed ID | |
Authors |
Prasanna Kulkarni, Poornima Devkumar, Indranil Chattopadhyay |
Abstract |
Differential alterations in gut microbiota and chronic low-grade inflammation play a critical role in the development of Type 2 diabetes (T2D). Here we aimed to investigate if dysbiosis of inflammation and anti-inflammation-associated gut bacterial communities in fecal samples of individuals had any influence on T2D using a 16S rRNA gene of V3 region sequencing at Illumina MiSeq platform. Our findings showed that a higher abundance of inflammatory bacteria such as Lactobacillus ruminis, Ruminococcus gnavus, Bacteroides caccae, Butyricimonas, and Collinsella aerofaciens, and lower abundance of anti-inflammatory bacteria such as Faecalibacterium prausnitzii, and Butyrivibrio that likely play a role in the development of T2D. Our findings hint the potential of indigenous microbiota in developing diagnostic markers and therapeutic targets in T2D. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 49 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 18% |
Student > Master | 5 | 10% |
Student > Bachelor | 3 | 6% |
Lecturer | 2 | 4% |
Professor | 2 | 4% |
Other | 6 | 12% |
Unknown | 22 | 45% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 9 | 18% |
Medicine and Dentistry | 5 | 10% |
Agricultural and Biological Sciences | 4 | 8% |
Nursing and Health Professions | 3 | 6% |
Immunology and Microbiology | 3 | 6% |
Other | 3 | 6% |
Unknown | 22 | 45% |