Title |
A hypothesis on chemical mechanism of the effect of hydrogen
|
---|---|
Published in |
Medical Gas Research, June 2012
|
DOI | 10.1186/2045-9912-2-17 |
Pubmed ID | |
Authors |
Penghui Shi, Wancang Sun, Pengzhong Shi |
Abstract |
Many studies have shown that hydrogen can play important roles on the antioxidant, anti-inflammatory and other protective effects. Ohsawa et al have proved that hydrogen can electively and directly scavenge hydroxyl radical. But this mechanism cannot explain more new experimental results. In this article, the hypothesis, which is inspired by H2 could bind to the metal as a ligand, come up to explain its extensive biology effect: Hydrogen could regulate particular metalloproteins by bonding (M-H2 interaction) it. And then it could affect the metabolization of ROS and signal transduction. Metalloproteins may be ones of the target molecules of H2 action. Metal ions may be appropriate role sites for H2 molecules. The hypothesis pointed out a new direction to clarify its mechanisms. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 16 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 2 | 13% |
Librarian | 2 | 13% |
Student > Ph. D. Student | 2 | 13% |
Lecturer > Senior Lecturer | 1 | 6% |
Lecturer | 1 | 6% |
Other | 4 | 25% |
Unknown | 4 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 4 | 25% |
Biochemistry, Genetics and Molecular Biology | 2 | 13% |
Environmental Science | 1 | 6% |
Earth and Planetary Sciences | 1 | 6% |
Agricultural and Biological Sciences | 1 | 6% |
Other | 2 | 13% |
Unknown | 5 | 31% |