Title |
Identification of novel growth phase- and media-dependent small non-coding RNAs in Streptococcus pyogenes M49 using intergenic tiling arrays
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Published in |
BMC Genomics, October 2012
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DOI | 10.1186/1471-2164-13-550 |
Pubmed ID | |
Authors |
Nadja Patenge, André Billion, Peter Raasch, Jana Normann, Aleksandra Wisniewska-Kucper, Julia Retey, Valesca Boisguérin, Thomas Hartsch, Torsten Hain, Bernd Kreikemeyer |
Abstract |
Small non-coding RNAs (sRNAs) have attracted attention as a new class of gene regulators in both eukaryotes and bacteria. Genome-wide screening methods have been successfully applied in Gram-negative bacteria to identify sRNA regulators. Many sRNAs are well characterized, including their target mRNAs and mode of action. In comparison, little is known about sRNAs in Gram-positive pathogens. In this study, we identified novel sRNAs in the exclusively human pathogen Streptococcus pyogenes M49 (Group A Streptococcus, GAS M49), employing a whole genome intergenic tiling array approach. GAS is an important pathogen that causes diseases ranging from mild superficial infections of the skin and mucous membranes of the naso-pharynx, to severe toxic and invasive diseases. |
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Mendeley readers
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