The co-evolution of the genome and epigenome in colorectal cancer
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Main Clonal evolution, fuelled by intra-tumour heterogeneity, drives tumour initiation, progression and treatment resistance8,9.
Main Clonal evolution, fuelled by intra-tumour heterogeneity, drives tumour initiation, progression and treatment resistance8,9.
Abstract Gains and losses of DNA are prevalent in cancer and emerge as a consequence of inter-related processes of replication…