Sweet's syndrome – a comprehensive review of an acute febrile neutrophilic dermatosis

RT @DrCindyCooper: @KirtanPatolia Awesome! Sweet syndrome - eponym acute febrile neutrophilic dermatosis - painful violaceous nodules/plaqu…

@KirtanPatolia Awesome! Sweet syndrome - eponym acute febrile neutrophilic dermatosis - painful violaceous nodules/plaques typically on neck/UE. Idiopathic or triggered infection, IBD, pregnancy or malignancy - most often AML. After G-CSF. Rapid response

12/15 Extracutaneous sites potentially involved - Bones (sterile OM in ped) - CNS, ears, eyes - Kidneys - GIT (incl mouth), liver - Heart, lung - Muscles - Spleen Table from https://t.co/BqJ07vbDUr https://t.co/8k4ok7pEjc

11/15 Typical HP - Diffuse mature PMN infiltrate in upper dermis - Dermal edema - (+/-) karyorrhexis (PMN nuc fragments), swollen endoth, dilated small bld vessels - Epidermis N - Usually no fibrin/PMNs in vessel wall - Stains for organisms (-) Fig from ht