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Attention Score in Context
| Title |
A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation
|
|---|---|
| Published in |
Genome Biology, January 2013
|
| DOI | 10.1186/gb-2013-14-10-r119 |
| Pubmed ID | |
| Authors |
Mario Iurlaro, Gabriella Ficz, David Oxley, Eun-Ang Raiber, Martin Bachman, Michael J Booth, Simon Andrews, Shankar Balasubramanian, Wolf Reik |
| Abstract |
DNA methylation (5mC) plays important roles in epigenetic regulation of genome function. Recently, TET hydroxylases have been found to oxidise 5mC to hydroxymethylcytosine (5hmC), formylcytosine (5fC) and carboxylcytosine (5caC) in DNA. These derivatives have a role in demethylation of DNA but in addition may have epigenetic signaling functions in their own right. A recent study identified proteins which showed preferential binding to 5-methylcytosine (5mC) and its oxidised forms, where readers for 5mC and 5hmC showed little overlap, and proteins bound to further oxidation forms were enriched for repair proteins and transcription regulators. We extend this study by using promoter sequences as baits and compare protein binding patterns to unmodified or modified cytosine using DNA from mouse embryonic stem cell extracts. |
Twitter Demographics
The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 324 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| United Kingdom | 2 | <1% |
| Netherlands | 1 | <1% |
| Australia | 1 | <1% |
| Switzerland | 1 | <1% |
| Brazil | 1 | <1% |
| Japan | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 314 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 87 | 27% |
| Researcher | 72 | 22% |
| Student > Master | 36 | 11% |
| Student > Bachelor | 18 | 6% |
| Student > Doctoral Student | 16 | 5% |
| Other | 49 | 15% |
| Unknown | 46 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 109 | 34% |
| Biochemistry, Genetics and Molecular Biology | 83 | 26% |
| Chemistry | 36 | 11% |
| Medicine and Dentistry | 12 | 4% |
| Unspecified | 5 | 2% |
| Other | 24 | 7% |
| Unknown | 55 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 January 2023.
All research outputs
#19,512,854
of 24,003,070 outputs
Outputs from Genome Biology
#4,054
of 4,279 outputs
Outputs of similar age
#225,603
of 287,917 outputs
Outputs of similar age from Genome Biology
#166
of 175 outputs
Altmetric has tracked 24,003,070 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,279 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 287,917 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 175 others from the same source and published within six weeks on either side of this one. This one is in the 2nd percentile – i.e., 2% of its contemporaries scored the same or lower than it.