A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation

So we reasoned that methylation turnover is required for H3K4me1 deposition at active enhancers. We have previously identified WRD5, a member of the MLL3/4 containing WRAD complex, as a strong binder of 5fC - this is one possible mechanism. https://t.co/2