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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis
|
|---|---|
| Published in |
Journal of Neuroinflammation, July 2014
|
| DOI | 10.1186/1742-2094-11-124 |
| Pubmed ID | |
| Authors |
Conor Mc Guire, Lynn Elton, Peter Wieghofer, Jens Staal, Sofie Voet, Annelies Demeyer, Daniel Nagel, Daniel Krappmann, Marco Prinz, Rudi Beyaert, Geert van Loo |
| Abstract |
The paracaspase mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is crucial for lymphocyte activation through signaling to the transcription factor NF-κB. Besides functioning as a scaffold signaling protein, MALT1 also acts as a cysteine protease that specifically cleaves a number of substrates and contributes to specific T cell receptor-induced gene expression. Recently, small molecule inhibitors of MALT1 proteolytic activity were identified and shown to have promising anticancer properties in subtypes of B cell lymphoma. However, information on the therapeutic potential of small compound inhibitors that target MALT1 protease activity in autoimmunity is still lacking. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 2% |
| Denmark | 1 | 2% |
| Unknown | 59 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 31% |
| Student > Master | 12 | 20% |
| Student > Ph. D. Student | 7 | 11% |
| Student > Doctoral Student | 5 | 8% |
| Other | 3 | 5% |
| Other | 6 | 10% |
| Unknown | 9 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 15 | 25% |
| Biochemistry, Genetics and Molecular Biology | 11 | 18% |
| Medicine and Dentistry | 5 | 8% |
| Immunology and Microbiology | 5 | 8% |
| Chemistry | 4 | 7% |
| Other | 10 | 16% |
| Unknown | 11 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 March 2024.
All research outputs
#3,755,486
of 25,610,986 outputs
Outputs from Journal of Neuroinflammation
#750
of 2,966 outputs
Outputs of similar age
#35,669
of 240,064 outputs
Outputs of similar age from Journal of Neuroinflammation
#6
of 31 outputs
Altmetric has tracked 25,610,986 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,966 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,064 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.