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Mendeley readers
| Title |
Synergistic effects of oncolytic reovirus and docetaxel chemotherapy in prostate cancer
|
|---|---|
| Published in |
BMC Cancer, June 2011
|
| DOI | 10.1186/1471-2407-11-221 |
| Pubmed ID | |
| Authors |
Lucy Heinemann, Guy R Simpson, Angela Boxall, Timothy Kottke, Kate L Relph, Richard Vile, Alan Melcher, Robin Prestwich, Kevin J Harrington, Richard Morgan, Hardev S Pandha |
| Abstract |
Reovirus type 3 Dearing (T3D) has demonstrated oncolytic activity in vitro, in in vivo murine models and in early clinical trials. However the true potential of oncolytic viruses may only be realized fully in combination with other modalities such as chemotherapy, targeted therapy and radiotherapy. In this study, we examine the oncolytic activity of reovirus T3D and chemotherapeutic agents against human prostate cancer cell lines, with particular focus on the highly metastatic cell line PC3 and the chemotherapeutic agent docetaxel. Docetaxel is the standard of care for metastatic prostate cancer and acts by disrupting the normal process of microtubule assembly and disassembly. Reoviruses have been shown to associate with microtubules and may require this association for efficient viral replication. |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 4% |
| Malaysia | 1 | 1% |
| Colombia | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 62 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 13 | 19% |
| Student > Master | 10 | 15% |
| Researcher | 10 | 15% |
| Student > Doctoral Student | 9 | 13% |
| Student > Ph. D. Student | 9 | 13% |
| Other | 10 | 15% |
| Unknown | 7 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 21 | 31% |
| Medicine and Dentistry | 16 | 24% |
| Biochemistry, Genetics and Molecular Biology | 6 | 9% |
| Immunology and Microbiology | 5 | 7% |
| Business, Management and Accounting | 1 | 1% |
| Other | 7 | 10% |
| Unknown | 12 | 18% |