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Lectin of Concanavalin A as an anti-hepatoma therapeutic agent

Overview of attention for article published in Journal of Biomedical Science, January 2009
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2 Wikipedia pages

Citations

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155 Mendeley
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Title
Lectin of Concanavalin A as an anti-hepatoma therapeutic agent
Published in
Journal of Biomedical Science, January 2009
DOI 10.1186/1423-0127-16-10
Pubmed ID
Authors

Huan-Yao Lei, Chih-Peng Chang

Abstract

Liver cancer is the predominant cause of cancer mortality in males of Southern China and Taiwan. The current therapy is not satisfactory, and more effective treatments are needed. In the search for new therapies for liver tumor, we found that Concanavalin A (Con A), a lectin from Jack bean seeds, can have a potent anti-hepatoma effect. Con A after binding to the mannose moiety on the cell membrane glycoprotein is internalized preferentially to the mitochondria. An autophagy is triggered which leads to cell death. Con A as a T cell mitogen subsequently activates the immune response in the liver and results in the eradication of the tumor in a murine in situ hepatoma model. The liver tumor nodule formation is inhibited by the CD8+ T cells, and a tumor antigen-specific immune memory is established during the hepatic inflammation. The dual properties (autophagic cytotoxicity and immunomodulation) via the specific carbohydrate binding let Con A exert a potent anti-hepatoma therapeutic effect. The novel mechanism of the Con A anti-hepatoma effect is discussed. The prototype of Con with an anti-hepatoma activity gives support to the search for other natural lectins as anti-cancer compounds.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 155 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Ireland 1 <1%
Belgium 1 <1%
Unknown 152 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 33 21%
Student > Master 29 19%
Student > Bachelor 27 17%
Researcher 18 12%
Student > Doctoral Student 12 8%
Other 19 12%
Unknown 17 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 49 32%
Biochemistry, Genetics and Molecular Biology 28 18%
Chemistry 13 8%
Pharmacology, Toxicology and Pharmaceutical Science 10 6%
Medicine and Dentistry 9 6%
Other 30 19%
Unknown 16 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 May 2015.
All research outputs
#8,533,995
of 25,371,288 outputs
Outputs from Journal of Biomedical Science
#353
of 1,100 outputs
Outputs of similar age
#53,554
of 184,835 outputs
Outputs of similar age from Journal of Biomedical Science
#3
of 11 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,100 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 184,835 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.