Gene-dosage effects in Down syndrome and trisomic mouse models

Overview of attention for article published in Genome Biology, September 2004

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基因剂量（Gene dosage) 是指在基因组中某一特定基因的拷贝数. 例如，在E. coli中，CRISPR序列中包含多个保守重复序列，该序列具有较高基因剂量，而乳糖操纵子（lac operon）在基因组中只有一个拷贝，所以具有较低的基因剂量.

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