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Compositional difference in antioxidant and antibacterial activity of all parts of the Carica papaya using different solvents

Overview of attention for article published in BMC Chemistry, February 2016
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Title
Compositional difference in antioxidant and antibacterial activity of all parts of the Carica papaya using different solvents
Published in
BMC Chemistry, February 2016
DOI 10.1186/s13065-016-0149-0
Pubmed ID
Authors

Nazia Asghar, Syed Ali Raza Naqvi, Zaib Hussain, Nasir Rasool, Zulfiqar Ali Khan, Sohail Anjum Shahzad, Tauqir A. Sherazi, Muhammad Ramzan Saeed Ashraf Janjua, Saeed Ahmad Nagra, Muhammad Zia-Ul-Haq, Hawa Ze Jaafar

Abstract

Carica papaya is a well known medicinal plant used in the West and Asian countries to cope several diseases. Patients were advised to eat papaya fruit frequently during dengue fever epidemic in Pakistan by physicians. This study was conducted to establish Polyphenols, flavonoids and antioxidant potential profile of extracts of all major parts of the C. papaya with seven major solvents i.e. water, ethanol, methanol, n-butanol, dichloromethane, ethyl acetate, and n-hexane. TPC, TFC, antioxidant and antibacterial potential were determined using different aqueous and organic solvents in addition to the determination of trace element in leaves, pulp and peel of C. papaya. Total soluble phenolics and flavonoids were found in promising quantity (≈66 mg GAE/g) especially in case of methanol and ethanol extracts. Antioxidant activity using DPPH free radical scavenging assay indicated leaves, bark, roots and pulp extracts showed >75.0 % scavenging potential while leaves and pulp showed 84.9 and 80.9 % inhibition of peroxidation, respectively. Reducing power assay showed leaves, pulp and roots extracts active to reduce Fe(3+) to Fe(2+) ions. The antibacterial study showed pulp extract is the best to cope infectious action of bacteria. This study was conducted to test the medicinal profile of all parts of C. papaya by extracting secondary metabolites with organic and aqueous solvents. Ethanol and methanol both were found to be the best solvents of choice to extract natural products to get maximum medicinal benefits and could be used to medicinal formulation against different infectious diseases.Graphical abstractMedicinal evaluation of different parts of C. papaya.

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The data shown below were compiled from readership statistics for 228 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 228 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 59 26%
Student > Master 22 10%
Student > Ph. D. Student 14 6%
Researcher 11 5%
Lecturer 7 3%
Other 27 12%
Unknown 88 39%
Readers by discipline Count As %
Agricultural and Biological Sciences 22 10%
Biochemistry, Genetics and Molecular Biology 20 9%
Chemistry 20 9%
Pharmacology, Toxicology and Pharmaceutical Science 18 8%
Medicine and Dentistry 12 5%
Other 46 20%
Unknown 90 39%