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PAGA: graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells

Overview of attention for article published in Genome Biology, March 2019
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Citations

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1029 Dimensions

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Title
PAGA: graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells
Published in
Genome Biology, March 2019
DOI 10.1186/s13059-019-1663-x
Pubmed ID
Authors

F. Alexander Wolf, Fiona K. Hamey, Mireya Plass, Jordi Solana, Joakim S. Dahlin, Berthold Göttgens, Nikolaus Rajewsky, Lukas Simon, Fabian J. Theis

Abstract

Single-cell RNA-seq quantifies biological heterogeneity across both discrete cell types and continuous cell transitions. Partition-based graph abstraction (PAGA) provides an interpretable graph-like map of the arising data manifold, based on estimating connectivity of manifold partitions ( https://github.com/theislab/paga ). PAGA maps preserve the global topology of data, allow analyzing data at different resolutions, and result in much higher computational efficiency of the typical exploratory data analysis workflow. We demonstrate the method by inferring structure-rich cell maps with consistent topology across four hematopoietic datasets, adult planaria and the zebrafish embryo and benchmark computational performance on one million neurons.

X Demographics

X Demographics

The data shown below were collected from the profiles of 135 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 1,113 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 1113 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 265 24%
Researcher 195 18%
Student > Master 98 9%
Student > Bachelor 98 9%
Student > Doctoral Student 47 4%
Other 121 11%
Unknown 289 26%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 301 27%
Agricultural and Biological Sciences 162 15%
Computer Science 72 6%
Medicine and Dentistry 55 5%
Immunology and Microbiology 49 4%
Other 164 15%
Unknown 310 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 166. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 February 2024.
All research outputs
#250,043
of 25,765,370 outputs
Outputs from Genome Biology
#89
of 4,515 outputs
Outputs of similar age
#5,427
of 365,637 outputs
Outputs of similar age from Genome Biology
#4
of 61 outputs
Altmetric has tracked 25,765,370 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,515 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.5. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 365,637 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.