Flexible trial design in practice - stopping arms for lack-of-benefit and adding research arms mid-trial in STAMPEDE: a multi-arm multi-stage randomized controlled trial

RT @MRCCTU: Day 13 of #50DaysofMAMS - Flexible trial design in practice - stopping arms for lack-of-benefit and adding research arms mid-tr…

RT @Prof_Nick_James: For me, this is one our most key papers as it describes both stopping arms and importantly the means of adding new one…

RT @mattsydes: This is one of the key applied papers for MAMS Platform protocols, IMO. Discusses experiences of acting on multi-stage elem…

This is one of the key applied papers for MAMS Platform protocols, IMO. Discusses experiences of acting on multi-stage element (stopping recruitment to arms for lack-of-benefit)... ... & of why how & how to draw in new comparisons to an ongoing t